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The Temporal Order of Genetic and Pathway Alterations in Tumorigenesis
Cancer evolves through the accumulation of mutations, but the order in which mutations occur is poorly understood. Inference of a temporal ordering on the level of genes is challenging because clinically and histologically identical tumors often have few mutated genes in common. This heterogeneity m...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3206070/ https://ncbi.nlm.nih.gov/pubmed/22069497 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027136 |
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