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The geometry of partial fitness orders and an efficient method for detecting genetic interactions

We present an efficient computational approach for detecting genetic interactions from fitness comparison data together with a geometric interpretation using polyhedral cones associated to partial orderings. Genetic interactions are defined by linear forms with integer coefficients in the fitness va...

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Publicat a:J Math Biol
Autors principals: Lienkaemper, Caitlin, Lamberti, Lisa, Drain, James, Beerenwinkel, Niko, Gavryushkin, Alex
Format: Artigo
Idioma:Inglês
Publicat: Springer Berlin Heidelberg 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6153669/
https://ncbi.nlm.nih.gov/pubmed/29736875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00285-018-1237-7
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