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A mathematical framework to determine the temporal sequence of somatic genetic events in cancer
Human cancer is caused by the accumulation of genetic alterations in cells. Of special importance are changes that occur early during malignant transformation because they may result in oncogene addiction and represent promising targets for therapeutic intervention. Here we describe a computational...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2955151/ https://ncbi.nlm.nih.gov/pubmed/20864632 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009117107 |
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