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A mathematical framework to determine the temporal sequence of somatic genetic events in cancer
Human cancer is caused by the accumulation of genetic alterations in cells. Of special importance are changes that occur early during malignant transformation because they may result in oncogene addiction and represent promising targets for therapeutic intervention. Here we describe a computational...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2955151/ https://ncbi.nlm.nih.gov/pubmed/20864632 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009117107 |
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