An HNF4α-miRNA Inflammatory Feedback Circuit regulates Hepatocellular Oncogenesis

Hepatocyte nuclear factor 4α (HNF4α) is essential for liver development and hepatocyte function. Here, we show that transient inhibition of HNF4α initiates hepatocellular transformation through a microRNA-inflammatory feedback loop circuit consisting of miR-124, IL6R, STAT3, miR-24 and miR-629. More...

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Detalhes bibliográficos
Main Authors: Hatziapostolou, Maria, Polytarchou, Christos, Aggelidou, Eleni, Drakaki, Alexandra, Poultsides, George A., Jaeger, Savina A., Ogata, Hisanobu, Karin, Michael, Struhl, Kevin, Hadzopoulou-Cladaras, Margarita, Iliopoulos, Dimitrios
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251960/
https://ncbi.nlm.nih.gov/pubmed/22153071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.10.043
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