An HNF4α-miRNA Inflammatory Feedback Circuit regulates Hepatocellular Oncogenesis

Hepatocyte nuclear factor 4α (HNF4α) is essential for liver development and hepatocyte function. Here, we show that transient inhibition of HNF4α initiates hepatocellular transformation through a microRNA-inflammatory feedback loop circuit consisting of miR-124, IL6R, STAT3, miR-24 and miR-629. More...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Hatziapostolou, Maria, Polytarchou, Christos, Aggelidou, Eleni, Drakaki, Alexandra, Poultsides, George A., Jaeger, Savina A., Ogata, Hisanobu, Karin, Michael, Struhl, Kevin, Hadzopoulou-Cladaras, Margarita, Iliopoulos, Dimitrios
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2011
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251960/
https://ncbi.nlm.nih.gov/pubmed/22153071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.10.043
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak