An HNF4α-miRNA Inflammatory Feedback Circuit regulates Hepatocellular Oncogenesis

Hepatocyte nuclear factor 4α (HNF4α) is essential for liver development and hepatocyte function. Here, we show that transient inhibition of HNF4α initiates hepatocellular transformation through a microRNA-inflammatory feedback loop circuit consisting of miR-124, IL6R, STAT3, miR-24 and miR-629. More...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Hatziapostolou, Maria, Polytarchou, Christos, Aggelidou, Eleni, Drakaki, Alexandra, Poultsides, George A., Jaeger, Savina A., Ogata, Hisanobu, Karin, Michael, Struhl, Kevin, Hadzopoulou-Cladaras, Margarita, Iliopoulos, Dimitrios
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2011
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251960/
https://ncbi.nlm.nih.gov/pubmed/22153071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.10.043
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia