PTEN and PIK3CA gene copy numbers and poor outcomes in non-small cell lung cancer patients with gefitinib therapy

BACKGROUND: Preclinical studies in non-small cell lung cancer (NSCLC) suggest the interaction of PTEN and PI3K affects sensitivity to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). We investigated outcomes in relation to PTEN, PIK3CA and EGFR gene copy number, and chromos...

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Detalhes bibliográficos
Main Authors: Fidler, M J, Morrison, L E, Basu, S, Buckingham, L, Walters, K, Batus, M, Jacobson, K K, Jewell, S S, Coon, J, Bonomi, P D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Genetics and Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251891/
https://ncbi.nlm.nih.gov/pubmed/22095222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.494
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