Copy Number Amplification of the PIK3CA Gene Is Associated with Poor Prognosis in Non-lymph node metastatic Head and Neck Squamous Cell Carcinoma

BACKGROUND: Deregulation of the EGFR signaling pathway is one of the most frequently observed genetic abnormalities that drives cancer development. Although mutations in the downstream components of the EGFR signaling pathway, including KRAS, BRAF and PIK3CA, have been reported in numerous cancers,...

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Detalhes bibliográficos
Main Authors: Suda, Toshihito, Hama, Takanori, Kondo, Shu, Yuza, Yuki, Yoshikawa, Mamoru, Urashima, Mitsuyoshi, Kato, Takakuni, Moriyama, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3518180/
https://ncbi.nlm.nih.gov/pubmed/22994622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-12-416
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