Copy Number Amplification of the PIK3CA Gene Is Associated with Poor Prognosis in Non-lymph node metastatic Head and Neck Squamous Cell Carcinoma

<p>Abstract</p> <p>Background</p> <p>Deregulation of the EGFR signaling pathway is one of the most frequently observed genetic abnormalities that drives cancer development. Although mutations in the downstream components of the EGFR signaling pathway, including KRAS, BR...

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Detalhes bibliográficos
Main Authors: Suda Toshihito, Hama Takanori, Kondo Shu, Yuza Yuki, Yoshikawa Mamoru, Urashima Mitsuyoshi, Kato Takakuni, Moriyama Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2012-09-01
Colecção:BMC Cancer
Assuntos:
PIK3CA
KRAS
BRAF
Copy number analysis
Prognostic Factor
Acesso em linha:http://www.biomedcentral.com/1471-2407/12/416
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