Distinct Effects of Alcohol Consumption and Smoking on Genetic Alterations in Head and Neck Carcinoma

BACKGROUND: Tobacco and alcohol consumption are risk factors for head and neck squamous cell carcinoma (HNSCC). Recently, whole-exome sequencing clarified that smoking increased TP53 and other mutations in HNSCC; however, the effects of alcohol consumption on these genetic alterations remain unknown...

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Detalhes bibliográficos
Main Authors: Urashima, Mitsuyoshi, Hama, Takanori, Suda, Toshihito, Suzuki, Yutaka, Ikegami, Masahiro, Sakanashi, Chikako, Akutsu, Taisuke, Amagaya, Suguru, Horiuchi, Kazuhumi, Imai, Yu, Mezawa, Hidetoshi, Noya, Miki, Nakashima, Akio, Mafune, Aki, Kato, Takakuni, Kojima, Hiromi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3835411/
https://ncbi.nlm.nih.gov/pubmed/24278325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0080828
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