COPY NUMBER GAINS IN EGFR AND COPY NUMBER LOSSES IN PTEN ARE COMMON EVENTS IN OSTEOSARCOMA TUMORS

BACKGROUND: Osteosarcoma cell lines and tumors have been shown to express EGFR and harbor amplifications at the EGFR locus. In this study, we further analyze the genomic features of EGFR in osteosarcoma tumors and investigate whether they correlate with PTEN expression and copy number status. METHOD...

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Detalhes bibliográficos
Main Authors: Freeman, Serena S., Allen, Steven W., Ganti, Ramapriya, Wu, Jianrong, Ma, Jing, Su, Xiaoping, Neale, Geoff, Dome, Jeffrey S., Daw, Najat C., Khoury, Joseph D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529469/
https://ncbi.nlm.nih.gov/pubmed/18704985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.23782
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