Fitness costs limit influenza A virus hemagglutinin glycosylation as an immune evasion strategy

Here, we address the question of why the influenza A virus hemagglutinin (HA) does not escape immunity by hyperglycosylation. Uniquely among dozens of monoclonal antibodies specific for A/Puerto Rico/8/34, escape from H28-A2 neutralization requires substitutions introducing N-linked glycosylation at...

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Autores principales: Das, Suman R., Hensley, Scott E., David, Alexandre, Schmidt, Loren, Gibbs, James S., Puigbò, Pere, Ince, William L., Bennink, Jack R., Yewdell, Jonathan W.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2011
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PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251056/
https://ncbi.nlm.nih.gov/pubmed/22106257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1108754108
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