Hemagglutinin Receptor Binding Avidity Drives Influenza A Virus Antigenic Drift

Rapid antigenic evolution in the influenza A virus hemagglutinin precludes effective vaccination with existing vaccines. To understand this phenomenon, we passaged virus in mice immunized with influenza. Neutralizing antibodies selected mutants with single amino acid hemagglutinin substitutions that...

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Main Authors: Hensley, Scott E., Das, Suman R., Bailey, Adam L., Schmidt, Loren M., Hickman, Heather D., Jayaraman, Akila, Viswanathan, Karthik, Raman, Rahul, Sasisekharan, Ram, Bennink, Jack R., Yewdell, Jonathan W.
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2784927/
https://ncbi.nlm.nih.gov/pubmed/19900932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1178258
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