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Hemagglutinin Receptor Binding Avidity Drives Influenza A Virus Antigenic Drift
Rapid antigenic evolution in the influenza A virus hemagglutinin precludes effective vaccination with existing vaccines. To understand this phenomenon, we passaged virus in mice immunized with influenza. Neutralizing antibodies selected mutants with single amino acid hemagglutinin substitutions that...
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| Auteurs principaux: | , , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2784927/ https://ncbi.nlm.nih.gov/pubmed/19900932 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1178258 |
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