Hemagglutinin Receptor Binding Avidity Drives Influenza A Virus Antigenic Drift

Rapid antigenic evolution in the influenza A virus hemagglutinin precludes effective vaccination with existing vaccines. To understand this phenomenon, we passaged virus in mice immunized with influenza. Neutralizing antibodies selected mutants with single amino acid hemagglutinin substitutions that...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Hensley, Scott E., Das, Suman R., Bailey, Adam L., Schmidt, Loren M., Hickman, Heather D., Jayaraman, Akila, Viswanathan, Karthik, Raman, Rahul, Sasisekharan, Ram, Bennink, Jack R., Yewdell, Jonathan W.
Format: Artigo
Langue:Inglês
Publié: 2009
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2784927/
https://ncbi.nlm.nih.gov/pubmed/19900932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1178258
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires