Structural Determinants for Naturally Evolving H5N1 Hemagglutinin to Switch its Receptor Specificity

Of the factors governing human-to-human transmission of the highly pathogenic avian-adapted H5N1 virus, the most critical is the acquisition of mutations on the viral hemagglutinin (HA) to “quantitatively switch” its binding from avian to human glycan receptors. Herein, we describe a structural fram...

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Main Authors: Tharakaraman, Kannan, Raman, Rahul, Viswanathan, Karthik, Stebbins, Nathan W., Jayaraman, Akila, Krishnan, Arvind, Sasisekharan, V., Sasisekharan, Ram
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3760228/
https://ncbi.nlm.nih.gov/pubmed/23746829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.05.035
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