Defining Influenza A Virus Hemagglutinin Antigenic Drift by Sequential Monoclonal Antibody Selection

Human influenza A virus (IAV) vaccination is limited by “antigenic drift,” rapid antibody-driven escape reflecting amino acid substitutions in the globular domain of hemagglutinin (HA), the viral attachment protein. To better understand drift, we used anti-hemagglutinin monoclonal Abs (mAbs) to sequ...

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Hauptverfasser: Das, Suman R., Hensley, Scott E., Ince, William L., Brooke, Christopher B., Subba, Anju, Delboy, Mark G., Russ, Gustav, Gibbs, James S., Bennink, Jack R., Yewdell, Jonathan W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3747226/
https://ncbi.nlm.nih.gov/pubmed/23498956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2013.02.008
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