Glycosylation Focuses Sequence Variation in the Influenza A Virus H1 Hemagglutinin Globular Domain

Antigenic drift in the influenza A virus hemagglutinin (HA) is responsible for seasonal reformulation of influenza vaccines. Here, we address an important and largely overlooked issue in antigenic drift: how does the number and location of glycosylation sites affect HA evolution in man? We analyzed...

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Bibliographic Details
Main Authors: Das, Suman R., Puigbò, Pere, Hensley, Scott E., Hurt, Darrell E., Bennink, Jack R., Yewdell, Jonathan W.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2991263/
https://ncbi.nlm.nih.gov/pubmed/21124818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1001211
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