The Fate of Bacterial Cocaine Esterase (CocE): An In Vivo Study of CocE-Mediated Cocaine Hydrolysis, CocE Pharmacokinetics, and CocE Elimination

Cocaine abuse and toxicity remain widespread problems in the United States. Currently cocaine toxicity is treated only symptomatically, because there is no Food and Drug Administration-approved pharmacotherapy for this indication. To address the unmet need, a stabilized mutant of bacterial cocaine e...

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Detalhes bibliográficos
Main Authors: Brim, Remy L., Noon, Kathleen R., Collins, Gregory T., Stein, Aron, Nichols, Joseph, Narasimhan, Diwa, Ko, Mei-Chuan, Woods, James H., Sunahara, Roger K.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2012
Assuntos:
Drug Discovery and Translational Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251018/
https://ncbi.nlm.nih.gov/pubmed/21990608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.186049
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