Thermostable Variants of Cocaine Esterase for Long-Time Protection against Cocaine Toxicity

Enhancing cocaine metabolism by administration of cocaine esterase (CocE) has been recognized as a promising treatment strategy for cocaine overdose and addiction, because CocE is the most efficient native enzyme for metabolizing the naturally occurring cocaine yet identified. A major obstacle to th...

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Hlavní autoři: Gao, Daquan, Narasimhan, Diwahar L., Macdonald, Joanne, Brim, Remy, Ko, Mei-Chuan, Landry, Donald W., Woods, James H., Sunahara, Roger K., Zhan, Chang-Guo
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Pharmacology and Experimental Therapeutics 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684895/
https://ncbi.nlm.nih.gov/pubmed/18987161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.049486
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