Oncolytic Virus-Mediated Manipulation of DNA Damage Responses: Synergy With Chemotherapy in Killing Glioblastoma Stem Cells

BACKGROUND: Although both the alkylating agent temozolomide (TMZ) and oncolytic viruses hold promise for treating glioblastoma, which remains uniformly lethal, the effectiveness of combining the two treatments and the mechanism of their interaction on cancer stem cells are unknown. METHODS: We inves...

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Detalhes bibliográficos
Principais autores: Kanai, Ryuichi, Rabkin, Samuel D., Yip, Stephen, Sgubin, Donatella, Zaupa, Cecile M., Hirose, Yuichi, Louis, David N., Wakimoto, Hiroaki, Martuza, Robert L.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3250384/
https://ncbi.nlm.nih.gov/pubmed/22173583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djr509
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