Naive antibody gene-segment frequencies are heritable and unaltered by chronic lymphocyte ablation

A diverse antibody repertoire is essential for an effective adaptive immune response to novel molecular surfaces. Although past studies have observed common patterns of V-segment use, as well as variation in V-segment use between individuals, the relative contributions to variance from genetics, dis...

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Detalhes bibliográficos
Main Authors: Glanville, Jacob, Kuo, Tracy C., von Büdingen, H.-Christian, Guey, Lin, Berka, Jan, Sundar, Purnima D., Huerta, Gabriella, Mehta, Gautam R., Oksenberg, Jorge R., Hauser, Stephen L., Cox, David R., Rajpal, Arvind, Pons, Jaume
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3250199/
https://ncbi.nlm.nih.gov/pubmed/22123975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1107498108
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