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Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire

Antibody repertoire diversity, potentially as high as 10(11) unique molecules in a single individual, confounds characterization by conventional sequence analyses. In this study, we present a general method for assessing human antibody sequence diversity displayed on phage using massively parallel p...

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Detalhes bibliográficos
Main Authors: Glanville, Jacob, Zhai, Wenwu, Berka, Jan, Telman, Dilduz, Huerta, Gabriella, Mehta, Gautam R., Ni, Irene, Mei, Li, Sundar, Purnima D., Day, Giles M. R., Cox, David, Rajpal, Arvind, Pons, Jaume
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787155/
https://ncbi.nlm.nih.gov/pubmed/19875695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909775106
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