B cell exchange across the blood-brain barrier in multiple sclerosis

In multiple sclerosis (MS) pathogenic B cells likely act on both sides of the blood-brain barrier (BBB). However, it is unclear whether antigen-experienced B cells are shared between the CNS and the peripheral blood (PB) compartments. We applied deep repertoire sequencing of IgG heavy chain variable...

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Detalhes bibliográficos
Main Authors: von Büdingen, H.-Christian, Kuo, Tracy C., Sirota, Marina, van Belle, Christopher J., Apeltsin, Leonard, Glanville, Jacob, Cree, Bruce A., Gourraud, Pierre-Antoine, Schwartzburg, Amy, Huerta, Gabriella, Telman, Dilduz, Sundar, Purnima D., Casey, Tyler, Cox, David R., Hauser, Stephen L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533544/
https://ncbi.nlm.nih.gov/pubmed/23160197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI63842
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