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Mutant Huntingtin, Abnormal Mitochondrial Dynamics, Defective Axonal Transport of Mitochondria, and Selective Synaptic Degeneration in Huntington’s Disease

Huntington’s disease (HD) is a progressive, fatal neurodegenerative disease caused by an expanded polyglutamine repeats in the HD gene. HD is characterized by chorea, seizures, involuntary movements, dystonia, cognitive decline, intellectual impairment and emotional disturbances. Research into mutan...

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Détails bibliographiques
Auteurs principaux: Reddy, P. Hemachandra, Shirendeb, Ulziibat P.
Format: Artigo
Langue:Inglês
Publié: 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249480/
https://ncbi.nlm.nih.gov/pubmed/22080977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2011.10.016
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