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Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

Increasing evidence suggests that the accumulation of amyloid beta (Aβ) in synapses and synaptic mitochondria causes synaptic mitochondrial failure and synaptic degeneration in Alzheimer's disease (AD). The purpose of this study was to better understand the effects of Aβ in mitochondrial activi...

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Detalhes bibliográficos
Main Authors: Calkins, Marcus J., Manczak, Maria, Mao, Peizhong, Shirendeb, Ulziibat, Reddy, P. Hemachandra
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209824/
https://ncbi.nlm.nih.gov/pubmed/21873260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr381
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