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Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease

The purpose of this study was to investigate the link between mutant huntingtin (Htt) and neuronal damage in relation to mitochondria in Huntington's disease (HD). In an earlier study, we determined the relationship between mutant Htt and mitochondrial dynamics/synaptic viability in HD patients...

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Bibliografiske detaljer
Main Authors: Shirendeb, Ulziibat P., Calkins, Marcus J., Manczak, Maria, Anekonda, Vishwanath, Dufour, Brett, McBride, Jodi L., Mao, Peizhong, Reddy, P. Hemachandra
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2012
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3276281/
https://ncbi.nlm.nih.gov/pubmed/21997870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr475
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