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Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease

The objective of this study was to determine the protective effects of the mitochondria-targeted molecules MitoQ and SS31 in striatal neurons that stably express mutant huntingtin (Htt) (STHDhQ111/Q111) in Huntington's disease (HD). We studied mitochondrial and synaptic activities by measuring...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Yin, Xiangling, Manczak, Maria, Reddy, P. Hemachandra
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4986329/
https://ncbi.nlm.nih.gov/pubmed/26908605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw045
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