Nitric Oxide Storage and Transport in Cells Are Mediated by Glutathione S-Transferase P1-1 and Multidrug Resistance Protein 1 via Dinitrosyl Iron Complexes

Nitrogen monoxide (NO) plays a role in the cytotoxic mechanisms of activated macrophages against tumor cells by inducing iron release. We showed that NO-mediated iron efflux from cells required glutathione (GSH) (Watts, R. N., and Richardson, D. R. (2001) J. Biol. Chem. 276, 4724–4732) and that the...

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Hlavní autoři: Lok, Hiu Chuen, Rahmanto, Yohan Suryo, Hawkins, Clare L., Kalinowski, Danuta S., Morrow, Charles S., Townsend, Alan J., Ponka, Prem, Richardson, Des R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249115/
https://ncbi.nlm.nih.gov/pubmed/22084240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.310987
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