Nitrogen monoxide (NO)-mediated iron release from cells is linked to NO-induced glutathione efflux via multidrug resistance-associated protein 1

Nitrogen monoxide (NO) plays a role in the cytotoxic mechanisms of activated macrophages against tumor cells by inducing iron (Fe) release. We have shown that NO-mediated Fe efflux from cells required glutathione (GSH), and we have hypothesized that a GS–Fe–NO complex was released. Hence, we studied...

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Bibliographic Details
Main Authors: Watts, Ralph N., Hawkins, Clare, Ponka, Prem, Richardson, Des R.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2006
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472503/
https://ncbi.nlm.nih.gov/pubmed/16679408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0602515103
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