Enhanced glutathione depletion, protein adduct formation, and cytotoxicity following exposure to 4-hydroxy-2-nonenal (HNE) in cells expressing human multidrug resistance protein-1 (MRP1) together with human glutathione S-transferase-M1 (GSTM1)

4-hydroxy-2-nonenal (HNE) is one of the most reactive products of lipid peroxidation and has both cytotoxic and genotoxic effects in cells. Several enzymatic pathways have been reported to detoxify HNE, including conjugation by glutathione-S-transferases (GSTs). Removal of the resulting HNE-glutathi...

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Autors principals: Rudd, Lisa P., Kabler, Sandra L., Morrow, Charles S., Townsend, Alan J.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3221485/
https://ncbi.nlm.nih.gov/pubmed/21925487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2011.08.012
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