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Energetics of Cyclic AMP Binding to HCN Channel C Terminus Reveal Negative Cooperativity
Cyclic AMP binds to the HCN channel C terminus and variably stabilizes its open state. Using isothermal titration calorimetry, we show that cAMP binds to one subunit of tetrameric HCN2 and HCN4 C termini with high affinity (∼0.12 μm) and subsequently with low affinity (∼1 μm) to the remaining three...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3249114/ https://ncbi.nlm.nih.gov/pubmed/22084239 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.269563 |
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