Načítá se...
Energetics of Cyclic AMP Binding to HCN Channel C Terminus Reveal Negative Cooperativity
Cyclic AMP binds to the HCN channel C terminus and variably stabilizes its open state. Using isothermal titration calorimetry, we show that cAMP binds to one subunit of tetrameric HCN2 and HCN4 C termini with high affinity (∼0.12 μm) and subsequently with low affinity (∼1 μm) to the remaining three...
Uloženo v:
| Hlavní autoři: | , , |
|---|---|
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Biochemistry and Molecular Biology
2012
|
| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3249114/ https://ncbi.nlm.nih.gov/pubmed/22084239 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.269563 |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!
|