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Superoxide dismutase 1 encoding mutations linked to ALS adopts a spectrum of misfolded states
BACKGROUND: Mutations in superoxide dismutase 1 (SOD1), which are one cause of familial amyotrophic lateral sclerosis (fALS), induce misfolding and aggregation of the protein. Misfolding can be detected by the binding of antibodies raised against peptide epitopes that are normally buried in the nati...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3248846/ https://ncbi.nlm.nih.gov/pubmed/22094223 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-6-77 |
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