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Superoxide dismutase 1 encoding mutations linked to ALS adopts a spectrum of misfolded states

BACKGROUND: Mutations in superoxide dismutase 1 (SOD1), which are one cause of familial amyotrophic lateral sclerosis (fALS), induce misfolding and aggregation of the protein. Misfolding can be detected by the binding of antibodies raised against peptide epitopes that are normally buried in the nati...

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Bibliografski detalji
Glavni autori: Prudencio, Mercedes, Borchelt, David R
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248846/
https://ncbi.nlm.nih.gov/pubmed/22094223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-6-77
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