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Superoxide dismutase 1 encoding mutations linked to ALS adopts a spectrum of misfolded states
BACKGROUND: Mutations in superoxide dismutase 1 (SOD1), which are one cause of familial amyotrophic lateral sclerosis (fALS), induce misfolding and aggregation of the protein. Misfolding can be detected by the binding of antibodies raised against peptide epitopes that are normally buried in the nati...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
BioMed Central
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3248846/ https://ncbi.nlm.nih.gov/pubmed/22094223 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-6-77 |
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