TNF receptor–associated factor 6 interacts with ALS-linked misfolded superoxide dismutase 1 and promotes aggregation

Amyotrophic lateral sclerosis (ALS) is a fatal disease, characterized by the selective loss of motor neurons leading to paralysis. Mutations in the gene encoding superoxide dismutase 1 (SOD1) are the second most common cause of familial ALS, and considerable evidence suggests that these mutations re...

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Pubblicato in:J Biol Chem
Autori principali: Semmler, Sabrina, Gagné, Myriam, Garg, Pranav, Pickles, Sarah R., Baudouin, Charlotte, Hamon-Keromen, Emeline, Destroismaisons, Laurie, Khalfallah, Yousra, Chaineau, Mathilde, Caron, Elise, Bayne, Andrew N., Trempe, Jean-François, Cashman, Neil R., Star, Alexandra T., Haqqani, Arsalan S., Durcan, Thomas M., Meiering, Elizabeth M., Robertson, Janice, Grandvaux, Nathalie, Plotkin, Steven S., McBride, Heidi M., Vande Velde, Christine
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2020
Soggetti:
Molecular Bases of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7086032/
https://ncbi.nlm.nih.gov/pubmed/32029478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011215
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