Evidence for Sequential and Increasing Activation of Replication Origins along Replication Timing Gradients in the Human Genome

Genome-wide replication timing studies have suggested that mammalian chromosomes consist of megabase-scale domains of coordinated origin firing separated by large originless transition regions. Here, we report a quantitative genome-wide analysis of DNA replication kinetics in several human cell type...

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Autores principales: Guilbaud, Guillaume, Rappailles, Aurélien, Baker, Antoine, Chen, Chun-Long, Arneodo, Alain, Goldar, Arach, d'Aubenton-Carafa, Yves, Thermes, Claude, Audit, Benjamin, Hyrien, Olivier
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2011
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248390/
https://ncbi.nlm.nih.gov/pubmed/22219720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002322
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