Evidence for sequential and increasing activation of replication origins along replication timing gradients in the human genome.

Genome-wide replication timing studies have suggested that mammalian chromosomes consist of megabase-scale domains of coordinated origin firing separated by large originless transition regions. Here, we report a quantitative genome-wide analysis of DNA replication kinetics in several human cell type...

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Detalhes bibliográficos
Principais autores: Guillaume Guilbaud, Aurélien Rappailles, Antoine Baker, Chun-Long Chen, Alain Arneodo, Arach Goldar, Yves d'Aubenton-Carafa, Claude Thermes, Benjamin Audit, Olivier Hyrien
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2011-12-01
coleção:PLoS Computational Biology
Acesso em linha:http://europepmc.org/articles/PMC3248390?pdf=render
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