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Evidence for sequential and increasing activation of replication origins along replication timing gradients in the human genome.
Genome-wide replication timing studies have suggested that mammalian chromosomes consist of megabase-scale domains of coordinated origin firing separated by large originless transition regions. Here, we report a quantitative genome-wide analysis of DNA replication kinetics in several human cell type...
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| Główni autorzy: | , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Public Library of Science (PLoS)
2011-12-01
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| Seria: | PLoS Computational Biology |
| Dostęp online: | http://europepmc.org/articles/PMC3248390?pdf=render |
| Etykiety: |
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