Open chromatin encoded in DNA sequence is the signature of ‘master’ replication origins in human cells

For years, progress in elucidating the mechanisms underlying replication initiation and its coupling to transcriptional activities and to local chromatin structure has been hampered by the small number (approximately 30) of well-established origins in the human genome and more generally in mammalian...

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Bibliographic Details
Main Authors: Audit, Benjamin, Zaghloul, Lamia, Vaillant, Cédric, Chevereau, Guillaume, d'Aubenton-Carafa, Yves, Thermes, Claude, Arneodo, Alain
Format: Artigo
Language:Inglês
Published: Oxford University Press 2009
Subjects:
Genomics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764438/
https://ncbi.nlm.nih.gov/pubmed/19671527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp631
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