Replication Fork Polarity Gradients Revealed by Megabase-Sized U-Shaped Replication Timing Domains in Human Cell Lines

In higher eukaryotes, replication program specification in different cell types remains to be fully understood. We show for seven human cell lines that about half of the genome is divided in domains that display a characteristic U-shaped replication timing profile with early initiation zones at bord...

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Autors principals: Baker, Antoine, Audit, Benjamin, Chen, Chun-Long, Moindrot, Benoit, Leleu, Antoine, Guilbaud, Guillaume, Rappailles, Aurélien, Vaillant, Cédric, Goldar, Arach, Mongelard, Fabien, d'Aubenton-Carafa, Yves, Hyrien, Olivier, Thermes, Claude, Arneodo, Alain
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320577/
https://ncbi.nlm.nih.gov/pubmed/22496629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002443
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