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Mutant TDP-43 in motor neurons promotes the onset and progression of ALS in rats
Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration, which ultimately leads to paralysis and death. Mutation of TAR DNA binding protein 43 (TDP-43) has been linked to the development of an inherited form of ALS. Existing TDP-43 transgenic animals develop a l...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Clinical Investigation
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3248298/ https://ncbi.nlm.nih.gov/pubmed/22156203 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI59130 |
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