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Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in rats

Mutation of Tar DNA-binding protein 43 (TDP-43) is linked to amyotrophic lateral sclerosis. Although astrocytes have important roles in neuron function and survival, their potential contribution to TDP-43 pathogenesis is unclear. Here, we created novel lines of transgenic rats that express a mutant...

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Библиографические подробности
Главные авторы: Tong, Jianbin, Huang, Cao, Bi, Fangfang, Wu, Qinxue, Huang, Bo, Liu, Xionghao, Li, Fang, Zhou, Hongxia, Xia, Xu-Gang
Формат: Artigo
Язык:Inglês
Опубликовано: European Molecular Biology Organization 2013
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3981181/
https://ncbi.nlm.nih.gov/pubmed/23714777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.122
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