Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis

DNA methyltransferase 3B (Dnmt3b) belongs to a family of enzymes responsible for methylation of cytosine residues in mammals. DNA methylation contributes to the epigenetic control of gene transcription and is deregulated in virtually all human tumors. To better understand the generation of cancer-sp...

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Bibliografiske detaljer
Main Authors: Hlady, Ryan A., Novakova, Slavomira, Opavska, Jana, Klinkebiel, David, Peters, Staci L., Bies, Juraj, Hannah, Jay, Iqbal, Javeed, Anderson, Kristi M., Siebler, Hollie M., Smith, Lynette M., Greiner, Timothy C., Bastola, Dhundy, Joshi, Shantaram, Lockridge, Oksana, Simpson, Melanie A., Felsher, Dean W., Wagner, Kay-Uwe, Chan, Wing C., Christman, Judith K., Opavsky, Rene
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248285/
https://ncbi.nlm.nih.gov/pubmed/22133874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI57292
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