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Influence of methotrexate on infliximab pharmacokinetics and pharmacodynamics in ankylosing spondylitis

AIMS: Infliximab, an anti-tumour necrosis factor α monoclonal antibody, has profoundly modified the treatment of several inflammatory diseases. The objective was to assess the influence of methotrexate on the variability of infliximab pharmacokinetics and concentration–effect relationship in axial a...

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Bibliografiske detaljer
Main Authors: Ternant, David, Mulleman, Denis, Lauféron, Francine, Vignault, Céline, Ducourau, Emilie, Wendling, Daniel, Goupille, Philippe, Paintaud, Gilles
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248256/
https://ncbi.nlm.nih.gov/pubmed/21692827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2011.04050.x
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