Mas-related Gene X2 (MrgX2) Is a Novel G Protein-coupled Receptor for the Antimicrobial Peptide LL-37 in Human Mast Cells: RESISTANCE TO RECEPTOR PHOSPHORYLATION, DESENSITIZATION, AND INTERNALIZATION

Human LL-37 is a multifunctional antimicrobial peptide that promotes inflammation, angiogenesis, wound healing, and tumor metastasis. Most effects of LL-37 are mediated via the activation of the cell surface G protein-coupled receptor FPR2 on leukocytes and endothelial cells. Although LL-37 induces...

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Detalhes bibliográficos
Main Authors: Subramanian, Hariharan, Gupta, Kshitij, Guo, Qiang, Price, Ryan, Ali, Hydar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3247983/
https://ncbi.nlm.nih.gov/pubmed/22069323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.277152
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