PMX-53 as a Dual CD88 Antagonist and an Agonist for Mas-Related Gene 2 (MrgX2) in Human Mast Cells

Human mast cells express the G protein coupled receptor (GPCR) for C5a (CD88). Previous studies indicated that C5a could cause mast cell degranulation, at least in part, via a mechanism similar to that proposed for basic neuropeptides such as substance P, possibly involving Mas-related gene 2 (MrgX2...

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Detalhes bibliográficos
Main Authors: Subramanian, Hariharan, Kashem, Sakeen W., Collington, Sarah J., Qu, Hongchang, Lambris, John D., Ali, Hydar
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3102546/
https://ncbi.nlm.nih.gov/pubmed/21441599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.111.071472
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