The Interface between Catalytic and Hemopexin Domains in Matrix Metalloproteinase-1 Conceals a Collagen Binding Exosite

Matrix metalloproteinase-1 (MMP-1) is an instigator of collagenolysis, the catabolism of triple helical collagen. Previous studies have implicated its hemopexin (HPX) domain in binding and possibly destabilizing the collagen substrate in preparation for hydrolysis of the polypeptide backbone by the...

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Bibliographic Details
Main Authors: Arnold, Laurence H., Butt, Louise E., Prior, Stephen H., Read, Christopher M., Fields, Gregg B., Pickford, Andrew R.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Molecular Biophysics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3247971/
https://ncbi.nlm.nih.gov/pubmed/22030392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.285213
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