The Interface between Catalytic and Hemopexin Domains in Matrix Metalloproteinase-1 Conceals a Collagen Binding Exosite

Matrix metalloproteinase-1 (MMP-1) is an instigator of collagenolysis, the catabolism of triple helical collagen. Previous studies have implicated its hemopexin (HPX) domain in binding and possibly destabilizing the collagen substrate in preparation for hydrolysis of the polypeptide backbone by the...

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Detalhes bibliográficos
Main Authors: Arnold, Laurence H., Butt, Louise E., Prior, Stephen H., Read, Christopher M., Fields, Gregg B., Pickford, Andrew R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3247971/
https://ncbi.nlm.nih.gov/pubmed/22030392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.285213
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