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Transgenic inhibition of Nogo-66 receptor function allows axonal sprouting and improved locomotion after spinal injury

Axon growth after spinal injury is thought to be limited in part by myelin-derived proteins that act via the Nogo-66 Receptor (NgR). To test this hypothesis, we sought to study recovery from spinal cord injury (SCI) after inhibiting NgR transgenically with a soluble function-blocking NgR fragment. G...

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Detalhes bibliográficos
Main Authors: Li, Shuxin, Kim, Ji-Eun, Budel, Stephane, Hampton, Thomas G., Strittmatter, Stephen M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246391/
https://ncbi.nlm.nih.gov/pubmed/15866044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2004.12.008
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