Blockade of Nogo-66, Myelin-Associated Glycoprotein, and Oligodendrocyte Myelin Glycoprotein by Soluble Nogo-66 Receptor Promotes Axonal Sprouting and Recovery after Spinal Injury

The growth of injured axons in the adult mammalian CNS is limited after injury. Three myelin proteins, Nogo, MAG (myelin-associated glycoprotein), and OMgp (oligodendrocyte myelin glycoprotein), bind to the Nogo-66 receptor (NgR) and inhibit axonal growth in vitro. Transgenic or viral blockade of Ng...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Li, Shuxin, Liu, Betty P., Budel, Stephane, Li, Mingwei, Ji, Benxiu, Walus, Lee, Li, Weiwei, Jirik, Adrienna, Rabacchi, Sylvia, Choi, Eugene, Worley, Dane, Sah, Dinah W. Y., Pepinsky, Blake, Lee, Daniel, Relton, Jane, Strittmatter, Stephen M.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2004
Subjects:
Development/Plasticity/Repair
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6730300/
https://ncbi.nlm.nih.gov/pubmed/15548666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2828-04.2004
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