Nogo-A Interacts with the Nogo-66 Receptor through Multiple Sites to Create an Isoform-Selective Subnanomolar Agonist

Nogo is a myelin-derived protein that limits axonal regeneration after CNS injury. A short hydrophilic Nogo-66 loop between two hydrophobic domains of Nogo binds to a Nogo-66 receptor (NgR) to inhibit axonal outgrowth. Inhibition of axon outgrowth and cell spreading by a second Nogo domain, termed A...

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Autori principali: Hu, Fenghua, Liu, Betty P., Budel, Stephane, Liao, Ji, Chin, Joanna, Fournier, Alyson, Strittmatter, Stephen M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2005
Soggetti:
Development/Plasticity/Repair
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855126/
https://ncbi.nlm.nih.gov/pubmed/15930377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5235-04.2005
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